Selective neuronal death following exposure to methylenedioxypyrovalerone is accompanied by an inhibition of NMDA receptor NR2B subunit expression
作者: László István Gerecsei1 Tamás Balázsa1 Diego Echevarría2 Ágota Ádám1 Gergely Zachar1 and András Csillag1
作者单位: 1; e-mail: csillag.andras@med.semmelweis-univ.hu1Department of Anatomy
2 Histology and Embryology
3 Semmelweis University
4 Faculty of Medicine
5 Budapest
6 Hungary
7 1Institute of Neuroscience (UMH-CSIC)
8 Miguel Hernández University
9 Alicante
10 Spain
刊名: Acta Neurobiologiae Experimentalis, 2019, Vol.79 (79)
来源数据库: Exeley Inc.
原始语种摘要: In a previous study, methylenedioxypyrovalerone (MDPV), a designer drug of the cathinone family, caused selective enhancement of Caspase3 immunoreactive (Casp3+) apoptotic cells in the nucleus accumbens (NAc) of 7‑day‑old mice. To further elaborate on the mechanism underlying MDPV‑elicited apoptosis, here, we investigated the appearance of Casp3+ cells in developing neural tube explants of E12.5 mice, following MDPV treatment in vitro. Apoptotic cells appeared in large number in the pallium as radial progenitor cells and multipolar neurons, and in the subpallium including the future NAc, both in control and MDPV treated specimens. MDPV did not cause gross morphological changes in the neural tube or in the abundance of Casp3+ cells, based on a visual impression, though quantification was...
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来源刊物:
影响因子:1.977 (2012)

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关键词翻译
关键词翻译
  • expression 表示
  • subunit 亚单位
  • receptor 接受体
  • postembryonic 胚后期的
  • predominant 优势
  • dopaminergic 多巴胺能的多巴胺能的
  • whereas 鉴于
  • likely 大概
  • following 追踪
  • control 控制