The effect of bupropion augmentation of minocycline in the treatment of depression
作者: Monica BendaleSharon Ronald D'souzaVeeranjaneyulu AddepalliPravin Popatrao Kale
作者单位: 1SVKM’s NMIMS, Mumbai
2Mithibai Campus, Mumbai
刊名: Acta Neurobiologiae Experimentalis, 2019, Vol.79 (2), pp.217-224
来源数据库: Exeley Inc.
DOI: 10.21307/ane-2019-019
关键词: DepressionMonoaminesBupropionMinocyclineHippocampusCerebral cortex
原始语种摘要: The aim of the current study was to analyse the augmentation of minocycline with bupropion in treating depression. ‘Saline’ (10 ml/kg), ‘minocycline per se ’ (25 mg/kg), ‘minocycline per se ’ (50 mg/kg), ‘bupropion per se ’ (5 mg/kg), ‘bupropion per se ’ (10 mg/kg) and ‘bupropion + minocycline’ (5 mg/kg + 25 mg/kg each) were administered to mice via the intraperitoneal route. In the forced swim and tail suspension test, the immobility period was analysed after 30 min of the treatment. Monoamines like dopamine, norepinephrine and serotonin levels were analysed in brain areas such as the whole brain, hippocampus and cerebral cortex using an HPLC-fluorescence detector. Euthanasia of mice was performed 1 h after treatment. Comparison between the control group and combination therapy and other...
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影响因子:1.977 (2012)

  • bupropion 丁氨苯丙酮
  • minocycline 二甲胺四环素
  • depression 低地
  • serotonin 血清素
  • dopamine 多巴胺
  • antidepressant 抗抑郁药
  • effect 效应
  • immobility 不动性
  • treatment 处理
  • norepinephrine 正肾上腺素