Alteration of oxidative stress markers and behavior of rats in a novel model of depression
作者: Anna Gorlova1 Dmitrii Pavlov1 Eugene Zubkov2 Yana Zorkina2* Anatoly Inozemtsev1 Anna Morozova2 Vladimir Chekhonin23
作者单位: 1; e-mail: zorkina.ya@serbsky.ru1Lomonosov Moscow State University
2 Department of Neurobiology
3 Moscow
4 Russia
5 2Serbsky National Medical Research Center of Psychiatry and Narcology
6 Department of Fundamental and Applied Neurobiology
7 3Russian National Research Medical University
8 Department of Medical Nanobiotechnology
刊名: Acta Neurobiologiae Experimentalis, 2019, Vol.79 (79)
来源数据库: Exeley Inc.
原始语种摘要: Emotional stress is considered a serious pathogenetic factor of depression. In this study an ultrasound model of emotional stress developed in our laboratory was applied. It is characterized by the use of ultrasound as the stressor agent. Animals are triggered not by any organic or physical disturbances but by the perception of adverse information. This type of stress can induce depressive‑like behavioral changes in rodents, manifested by decreased sucrose preference and increased time of immobility in a forced swim test. Ultrasound stress also increased the levels of oxidative stress markers. This is important, as stress has an established association with increased oxidative processes in the central nervous system. Total glutathione and carbonyl protein content were selected as relevant...
全文获取路径: Exeley 公司 
影响因子:1.977 (2012)

  • stress 应力
  • oxidative 氧化的
  • depression 低地
  • markers 时标
  • ultrasound 超声
  • depressive 降低的
  • protein 蛋白质
  • increased 增加
  • demonstrated 探明的储量
  • induced 感应的