Development and Validation Method for the Determination of Sildenafil Citrate Tablets by using UV-Spectrophotometer in Pharmaceutical Formulation
作者: Alrasheed AW MohammedSalah Elnaiem MohammedHanaa S BoshraMuzamil Hassaballa Abdelmula
作者单位: 1Central Laboratory, Shambat Campus, Khartoum University, Sudan
刊名: BioTechnology: An Indian Journal, 2019, Vol.15 (2), pp.01-13
来源数据库: Trade Science Inc
关键词: Sildenafil citrateAbsorptionUV-spectrophotometer
原始语种摘要: The objective of this paper is to describe the optimization, validation, and application of spectrophotometric technique for determination of Sildenafil Citrate in their pharmaceutical formulation (tablets). In this paper, a simple, rapid, accurate and sensitive spectrophotometric method has been developed and validated. The method is a direct spectrophotometric method based on thawed of sildenafil citrate in diluted hydrochloric acid. The maximum absorption wavelength for the determination of Sildenafil citrate was found to be 295 nm. Under the optimized condition, Beer’s law was obeyed in the concentration range from 5.0-40.0 μg/ml.
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  • hydrochloric 盐酸的
  • determination 测定
  • pharmaceutical 
  • formulation 配方
  • paper 
  • validation 证实
  • maximum 最大值
  • objective 接物镜
  • citrate 柠檬酸盐
  • concentration 浓度