TGF-β signaling in hepatocellular carcinoma suppression and progression
作者: Hao JianChen DanYuan Jin-Wei
作者单位: 1Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
2School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
刊名: Traditional Medicine Research, 2018, Vol.3 (1), pp.10-21
来源数据库: TMR publishing group
原始语种摘要: Highlights This paper evaluates the suppressive and accelerant roles of TGF-β in hepatocellular carcinoma, discusses how a tumor-suppressor pathway can be so radically turned on its head and further provides some new molecular insights that may aid efforts towards targeted antitumor therapies. Editor’s Summary This review pays particular attention to the dual role of TGF-β in hepatocellular carcinoma. It also discusses the potential anti-tumor herbs through TGF-β signaling pathways. Abstract Derangements of several cell signaling pathways have been implicated in the initiation, progression, and development of hepatocellular carcinoma (HCC). One of such pathways is the activated TGF-β/Smad pathway. TGF-β inhibits proliferation and induces apoptosis in various cells types in the early...
全文获取路径: 传统医学研究 

  • hepatocellular 肝细胞性的
  • TGF 转化生长因子
  • carcinoma 癌症
  • signaling 发信号
  • antitumor 抗癌的
  • progression 级数
  • potential 
  • suppressive 压制
  • suppressor 抑制栅
  • targeted 对准目标的