Lower level of copper and zinc in serum confer risk to vitiligo: a systematic review and meta-analysis
作者: Tao-YangYi-BoCaoWan-LingLiangJian-XiaWenShi-ZhangWeiHao-TianLiTian-BaoXiao
刊名: TMR Clinical Research, 2019, Vol.2 (4)
来源数据库: TMR publishing group
DOI: 10.12032/TMRClinRes20191001015
关键词: VitiligoCopperZincSystematic reviewMeta analysis
原始语种摘要: Etiology and pathogenesis of vitiligo has not been interpreted perfectly. Epidemiologic evidence about falling level of copper and zinc in blood serum increasing the risk of vitiligo remains contradictory. We investigated the association between blood serum copper and zinc with vitiligo via performing a meta-analysis. Results indicates there was a significant lower level of copper and zinc in patients with vitiligo compared with healthy population ((Z = 3.55, P = 0.000; SMDCu = −0.84, 95% CI, −1.30 to −0.38) and (Z = 5.40, P = 0.000; SMDZn = −1.01, 95% CI, −1.38 to −0.64), respectively). Meanwhile, no statistical evidence for publication bias in the end outcome.Conclusion from our finding offers a meaningful insight into lower level of copper and zinc in serum confer risk to vitiligo.
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  • vitiligo 白斑
  • serum 血清
  • analysis 分析
  • level 水准
  • copper 
  • confer 授予
  • review 复审
  • systematic 有系统的
  • meaningful 有意义的
  • perfectly 完全地