Purpose: To strictly evaluate the quality of guidelines on risk factors related to secondary prevention of myocardial infarction (MI), and to summarize and analyze the relevant recommendations, and to provide evidence-based support for medical staff to develop interventions related risk factors for MI patients. Methods: The professional guideline websites and databases in English and Chinese were retrieved, and the references related guidelines were traced to get the published guidelines. Appraisal of Guidelines for Research and Evaluation II was used to evaluate the methodological quality of the guidelines. Then the relevant recommendations for MI were summarized and analyzed. Results: A total of 8 guidelines, including evidence-based guidelines and expert consensus were included in the... initial review of 2,099 articles, among which 2 from the UK, 1 from the US and 5 from China. The overall quality of the included guidelines is moderate. However, some guidelines score relatively low in the dimensions of rigor of development, clarity of presentations and editorial independence. A total of 24 items were extracted, including three risk factors: blood pressure, blood sugar and blood lipid. The recommendations mainly cover the relevant target values of risk factors, providing evidence-based support for medical staff to control and guide the risk factors of patients with MI in three aspects, such as blood pressure, blood sugar and blood lipid, which providing the theory basis for self-monitoring. Conclusions: It is recommended that clinical practice on risk factors of MI should be based on best evidence and fully put the individual factors into account.