Identification of key pathways and genes from gastric precancerous lesions to gastric cancer by integrated bioinformatics analysis
作者: Yang Liang-JunLi JingZhang ChiLi Yue-Jun
作者单位: 1Guangzhou University of Chinese Medicine, Guangzhou 510405, China
2The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410007, China
3Zhuzhou Hospital of Traditional Chinese Medicine, Zhuzhou 412008, China.
刊名: TMR Cancer, 2020, Vol.3 (1), pp.32-43
来源数据库: TMR publishing group
原始语种摘要: HighlightsThis study explored possible changes in gene expression during the transition from precancerous lesions to gastric cancer. Until now, the underlining mechanisms of precancerous lesions to cancer transition remain unclear. Bioinformatics analysis may find out genes that are differentially expressed in this process, and provide ideas for studying the transformation of precancerous lesions into cancer.(#br)Abstract Objective:(#br) This work aimed to illuminate the potential key genes and pathways in GC tumorigenesis based on bioinformatics analysis. Methods:(#br) The differentially expressed genes (DEGs) between GPL tissue samples and GC tissue samples were investigated using the GSE55696 and GSE87666 microarray data from the Gene Expression Omnibus (GEO) database. DEGs were...
全文获取路径: 传统医学研究  (合作)
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关键词翻译
关键词翻译
  • precancerous 癌症前期的
  • gastric 胃的
  • analysis 分析
  • bioinformatics 生物信息学
  • regulated 规定
  • pathway 轨道
  • tumorigenesis 瘤形成
  • protein 蛋白质
  • expressed 榨出的
  • signaling 发信号