|作者：||Jin Zi-Qi, Yuan Jin-Wei, Hao Jian, Wu Xiong-Zhi, Liang Jing|
1Tianjin Medical University, School of Basic Medical Sciences, Department of Pharmacology, Tianjin, China.
2Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
|刊名：||Traditional Medicine Research, 2018, Vol.3 (1), pp.1-9|
|来源数据库：||TMR publishing group|
|原始语种摘要：||Highlights This review summarized the toxicity and carcinogenesis of aristolochic acids and the underlying mechanisms. Editor’s Summary The mutational signature of aristolochic acids is related to the occurrence of HCC. However, the frequency of administration and dose, exposure time to aristolochic acids, and infectious situations of hepatitis B virus should also be further identified. Abstract Aristolochic acids (AAs), a natural mixture of 8-methoxy-6-nitro-phenanthro-(3,4-d)-1,3-dioxolo-5-carboxylic acid (AAI) and 6-nitro-phenanthro-(3,4-d)-1,3-dioxolo-5-carboxylic acid (AAII), derived from aristolochiaceae species, has been reported to cause AAS-induced nephropathy and upper urothelial cancer. In this review, we summarize the information on the nephrotoxicity and carcinogenesis of AAs... and their derivatives. AAs nephrotoxicity can lead to apoptosis and oxidative stress of renal tubular cells, and inhibition of the expression of aquaporins. AAs can also reduce the capability for renal tubular epithelial cell repair after acute injury and further produce renal fibrosis by activating TGF-β-Smad signaling and promoting the migration of macrophages. Moreover, AAs-induced carcinogenesis may be due to the formation of covalent adducts with DNA which can lead to the mutation in certain tumor suppressor genes or proto-oncogenes and the different catalyzing capacity of the microsomal cytochrome P450 of individuals in AAI metabolism.|