Nephrotoxicity and carcinogenesis of aristolochic acids and their derivates
作者: Jin Zi-QiYuan Jin-WeiHao JianWu Xiong-ZhiLiang Jing
作者单位: 1Tianjin Medical University, School of Basic Medical Sciences, Department of Pharmacology, Tianjin, China.
2Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
刊名: Traditional Medicine Research, 2018, Vol.3 (1), pp.1-9
来源数据库: TMR publishing group
原始语种摘要: Highlights This review summarized the toxicity and carcinogenesis of aristolochic acids and the underlying mechanisms. Editor’s Summary The mutational signature of aristolochic acids is related to the occurrence of HCC. However, the frequency of administration and dose, exposure time to aristolochic acids, and infectious situations of hepatitis B virus should also be further identified. Abstract Aristolochic acids (AAs), a natural mixture of 8-methoxy-6-nitro-phenanthro-(3,4-d)-1,3-dioxolo-5-carboxylic acid (AAI) and 6-nitro-phenanthro-(3,4-d)-1,3-dioxolo-5-carboxylic acid (AAII), derived from aristolochiaceae species, has been reported to cause AAS-induced nephropathy and upper urothelial cancer. In this review, we summarize the information on the nephrotoxicity and carcinogenesis of AAs...
全文获取路径: 传统医学研究 

  • 肝炎 纤维化
  • carcinogenesis 癌形成
  • nephrotoxicity 中毒性肾损害
  • tubular 管状的
  • carboxylic 类羧酸的
  • renal 肾的
  • their 他们的
  • induced 感应的
  • underlying 下伏的
  • fibrosis 纤维化
  • hepatitis 纤维化