Drug transporter pharmacogenetics in nucleoside-based therapies
作者: Ekaitz Errasti-MurugarrenMar&ccedilal Pastor-Anglada
作者单位: 11The Department of Biochemistry and Molecular Biology, Institute of Biomedicine, University of Barcelona, Diagonal 645, 08028 Barcelona, Spain
22Center for Biomedical Research Network in the Subject Area of Liver and Digestive Diseases (CIBERehd), Barcelona 08071, Spain
3 mpastor@ub.edu
刊名: Pharmacogenomics, 2010, Vol.11 (6), pp.809-841
来源数据库: Future Science Group Journal
DOI: 10.2217/pgs.10.70
关键词: ABCchemotherapynucleobasenucleosidepharmacogeneticsplasma membrane transporterpolymorphic variantSLC
原始语种摘要: This article focuses on the different types of transporter proteins that have been implicated in the influx and efflux of nucleoside-derived drugs currently used in the treatment of cancer, viral infections (i.e., AIDS) and other conditions, including autoimmune and inflammatory diseases. Genetic variations in nucleoside-derived drug transporter proteins encoded by the gene families SLC15 , SLC22 , SLC28 , SLC29 , ABCB , ABCC and ABCG will be specifically considered. Variants known to affect biological function are summarized, with a particular emphasis on those for which clinical correlations have already been established. Given that relatively little is known regarding the genetic variability of the players involved in determining nucleoside-derived drug bioavailability, it is...
全文获取路径: Future Science Group 
影响因子:3.857 (2012)

  • nucleoside 核苷
  • transporter 运送机
  • efflux 
  • derived 导生的
  • influx 
  • inflammatory 激怒的
  • AIDS Acoustic Intelligence Data System
  • currently 普遍地
  • proteins 蛋白质
  • autoimmune 自身免疫的