Aim. The current study carried out to investigate the possibility of microbial contaminated of drugs and biological products with detection of bacterial types contaminants then investigate the antibacterial effect of tea extracts. Materials and methods. Different local and imported drug types were collected from houses and some pharmacy during May to October 2013, bacterial counts and type of contaminant isolates were estimated by conventional methods, then antibacterial activity of tea extract were investigated on the isolated bacteria. Results. Syrup and drops type were the most contaminated drugs than other types of drugs, syrup reveals the highest rate of bacterial contamination (20%), while capsule reveals low rate (7.4%). Staphylococcus and Pseudomonas genera form the predominant... bacterial isolates (25.8 and 22.5 %) respectively, while, Proteus genus reveals rare appearance. Aqueous and alcoholic extracts of green and red tea shows antibacterial inhibitory effects against bacteria isolated from drugs. The lower minimum inhibitory concentration ( MIC ) appear on Staphylococcus 0.82 and 1.12 mg/ml with alcoholic and aqueous green tea extract respectively Although, microorganisms spread everywhere if a minimal growth requirements is presents, drugs and biological products should be completely sterile. Conclusion. Microbial contamination of drug samples appear with a percent 20% The most contaminant bacterial isolates was Staphylococcus spp. Alcoholic tea extracts appear to be the most effected than aqueous. Alcoholic extract reveals a lowest minimum inhibitory concentration on Staphylococcus spp.0.82 mg/ ml. Drugs from houses reveal high rate of bacterial contaminants.