A New Multicomponent DominoTransformation of 1,3-Dicarbonyl Compounds: One-Pot Regio-,Chemo- and Stereoselective Access to Valuable α,γ-Difunctionalized α-Ketoestersand Amides
作者: Hadjira Habib-ZahmaniSalih HaciniEmmanuelle CharonnetJean Rodriguez
刊名: Synlett, 2002, Vol.2002 (11), pp.1827-1830
来源数据库: Thieme Journal
DOI: 10.1055/s-2002-34874
关键词: multi-component reactionβ-ketoestersβ-ketoamidesαγ-difunctionalizationazaspiro derivatives
原始语种摘要: A new multi-component transformation between 1,3-dicarbonyls 1, aldehydes 2,and allylic, propargylic or benzylic halides 3 isdescribed. It provides a regio-, chemo- and stereoselective one-potaccess to α,γ-difunctionalized α-ketoestersand amides 4, bearing a quaternary centervaluable for further synthetic transformations via ring-closingmetathesis to give azaspiro systems found in bioactive natural products.
全文获取路径: Thieme 
影响因子:2.655 (2012)