Rapid Generation of Molecular Complexity: Synthesis of α-Hydroxyallenes Using Functionalized Grignard Reagents
作者: Carl DeutschAnja Hoffmann-RöderAxel DomkeNorbert Krause
刊名: Synlett, 2007, Vol.2007 (5), pp.0737-0740
来源数据库: Thieme Journal
DOI: 10.1055/s-2007-970768
关键词: alleneschirality transferfunctionalized Grignard ­reagentsorganocopper reagentsSN2′ substitution
英文摘要: The use of functionalized aryl-Grignard reagents in the copper-mediated S N 2′ substitution of propargylic oxiranes leads to structurally complex α-hydroxyallenes, usually with high yield and diastereoselectivity. Further transformations, such as gold-catalyzed cycloisomerization to 2,5-dihydrofurans and palladium-catalyzed coupling reactions, demonstrate the high potential of these compounds for the rapid generation of molecular complexity.
全文获取路径: Thieme 
影响因子:2.655 (2012)

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