Synthesis of Functionalized Spiroheterocycles by Sequential Multicomponent Reaction/Metal-Catalyzed Carbocylizations from Simple β-Ketoesters and Amides
作者: Hadjira Habib-ZahmaniJacques VialaSalih HaciniJean Rodriguez
刊名: Synlett, 2007, Vol.2007 (07), pp.1037-1042
来源数据库: Thieme Journal
DOI: 10.1055/s-2007-973896
关键词: multicomponent reactionsring-closing metathesisHeck reactionspiroheterocycles13-dicarbonyl compounds
英文摘要: A new strategy from simple cyclic β-ketoesters or amides involving a selective three-component reaction and a ring-closing metathesis or a palladium-catalyzed carbocyclization in a sequential fashion to access spiroheterocycles is reported. This ­expedient two-step sequence generates compounds of significant molecular complexity and high synthetic and biological relevance from simple and readily available starting materials.
全文获取路径: Thieme  (合作)
影响因子:2.655 (2012)