Mild and Direct Access to 7-Substituted-4-trifluoromethylpyrimido[1,2-b]pyridazin-2-one Systems
作者: Julien PetrignetEmilie ThieryLaurence SilpaMohamed Abarbri
刊名: Synthesis, 2014, pp.-
来源数据库: Thieme Journal
DOI: 10.1055/s-0033-1340664
关键词: ethyl 444-trifluorobutynoateaminopyridazineheterocyclizationtrifluoromethylpyrimido[12-b]pyridazin-2-oneSuzuki reaction
英文摘要: New and efficient methods for the synthesis of 7-substituted-4-trifluoromethylpyrimido[1,2-b]pyridazin-2-one derivatives using either two-step Suzuki/heterocyclization, or two-step heterocyclization/substitution sequences are developed. A variety of substituted products are obtained in good to excellent yields from 3-amino-6-chloropyridazine and ethyl 4,4,4-trifluorobut-2-ynoate.
全文获取路径: Thieme  (合作)
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影响因子:2.5 (2012)

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