Role of Transient Receptor Potential Canonical Channel 6 (TRPC6) in Diabetic Kidney Disease by Regulating Podocyte Actin Cytoskeleton Rearrangement
作者: Qian WangXuefei TianYuyang WangYan WangJialin LiTingting ZhaoPing LiEric Hajduch
作者单位: 1Beijing Key Laboratory for Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Sciences, China-Japan Friendship Hospital, Beijing 100029, China
2Beijing University of Chinese Medicine, Beijing 100029, China
3Section of Nephrology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
4Department of Nephrology, Guang’anmen Hospital of China Academy of Traditional Chinese Medical Sciences, Beijing 100053, China
5Beijing Key Laboratory of Diabetes Research and Care, Center for Endocrine Metabolism and Immune Diseases, Luhe Hospital, Capital Medical University, Beijing 101149, China
刊名: Journal of Diabetes Research, 2020, Vol.2020
来源数据库: Hindawi Journal
DOI: 10.1155/2020/6897390
原始语种摘要: Podocyte injury is an important pathogenesis step causing proteinuric kidney diseases such as diabetic kidney disease (DKD). Actin cytoskeleton rearrangement in podocyte induced by multiple pathogenic factors is believed to be the key process resulting in glomerular injury. Many studies have recently shown that transient receptor potential canonical channel 6 (TRPC6) in podocyte plays a critical role in the development and progression of proteinuric kidney disease by regulating its actin cytoskeleton rearrangement. This review is aimed at summarizing the role of TRPC6 on DKD by regulating the podocyte actin cytoskeleton rearrangement, thereby help further broaden our views and understanding on the mechanism of DKD and provide a theoretic basis for exploring new therapeutic targets for DKD...
全文获取路径: Hindawi  (合作)

  • podocyte 足状突细胞
  • kidney 肾脏
  • rearrangement 重新配置
  • regulating 蝶的
  • glomerular 肾小球病
  • cytoskeleton 细胞骨架
  • therapeutic 治疗的
  • understanding 理解
  • Kidney 
  • pathogenesis 发病机理