Aggressive Central Nervous System Relapse after Autologous Stem Cell Transplant in Multiple Myeloma: Case Reports and Literature Review
作者: Rui BergantimJuliana BastosMaria José SoaresBruno CarvalhoPedro SoaresCristina MarquesJennifer CostaJosé Eduardo GuimarãesFernanda TrigoVincent Ribrag
作者单位: 1Hematology Department, Centro Hospitalar São João, Porto, Portugal
2i3S—Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
3Cancer Drug Resistance Group, IPATIMUP—Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
4Hematology & Oncology Unit, Department of Medicine, Faculty of Medicine of University of Porto, Porto, Portugal
5Cytogenetics Laboratory, Hematology Department, Centro Hospitalar São João, Porto, Portugal
6Neurosurgery Department, Centro Hospitalar São João, Porto, Portugal
7Radiotherapy Department, Centro Hospitalar São João, Porto, Portugal
8Flow Cytometry Laboratory, Clinical Pathology Department, Centro Hospitalar São João, Porto, Portugal
9Pathologic Anatomy Department, Centro Hospitalar São João, Porto, Portugal
刊名: Case Reports in Hematology, 2020, Vol.2020
来源数据库: Hindawi Journal
DOI: 10.1155/2020/8563098
原始语种摘要: Extramedullary disease is an aggressive presentation at diagnosis and relapse for multiple myeloma (MM) patients. Central nervous system (CNS) is a very rare manifestation of the extramedullary disease, accounting for less than 1% of MM on diagnosis and relapse. Neurological symptoms are unspecific and usually attributed to other causes. We present two patients with CNS-MM at relapse after autologous stem cell transplant highlighting the importance of clinical suspicion and interdisciplinarity at diagnostic workup as well as the need for intensive therapeutic options on such rare and aggressive cases. The presence of neurological abnormalities in anamnesis and physical examination on a patient with MM should always prompt to suspect of a CNS involvement, and active investigation must be...
全文获取路径: Hindawi 
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关键词翻译
关键词翻译
  • presentation 提示
  • aggressive 侵蚀的
  • essential 本质的
  • systemic 系统的
  • unspecific 非特定的
  • intrathecal 墙间的
  • corroboration 坚定
  • anamnesis 既往症
  • extramedullary 髓外的
  • tailored 简明的