ALDH3B2 Polymorphism Is Associated with Colorectal Cancer Susceptibility
作者: Zhi-Gang GaoYong YangXiao-Feng HanYun-Lei WangZhen-Jun WangGiandomenico Roviello
作者单位: 1Department of General Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China
刊名: Journal of Oncology, 2020, Vol.2020
来源数据库: Hindawi Journal
DOI: 10.1155/2020/5179635
原始语种摘要: Colorectal cancer (CRC) is the 5th leading cancer in China. Alcohol consumption has been reported to be one of the risk factors of CRC. However, it remains unclear whether genetic variants of alcohol metabolic genes are associated with CRC risk. In this study, we tested the coding variants in the alcohol metabolic genes and the risk of CRC, by using 485 cases and 516 controls. A total of 16 germline coding variants in 10 alcohol metabolic genes were genotyped. We identified that rs3741178 in ALDH3B2 was significantly associated with CRC risk with odds ratio being 2.13 (95% CI: 1.24–3.68, P = 0.0064 ). Further functional annotation suggested that this variant may damage the protein function of ALDH3B2. Our results suggested that ALDH3B2 in the alcohol metabolism pathway contributed to the...
全文获取路径: Hindawi  (合作)
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关键词翻译
关键词翻译
  • Carriage Return Contact 消耗
  • alcohol 
  • suggested 建议
  • coding 编码
  • functional 功能的
  • contribute 贡献
  • consumption 消耗
  • CRC 消耗
  • associated 相关的
  • metabolic 新陈代谢的
  • protein 蛋白质