Gamma Radiation-Induced Damage in the Zinc Finger of the Transcription Factor IIIA
作者: XiaoHong ZhangYuJi MiaoXiaoDan HuRui MinPeiDang LiuHaiQian ZhangMassimiliano F. Peana
作者单位: 1Department of Nuclear Science and Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210016, China
2Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, Nanjing 210009, China
3Collaborative Innovation Center of Radiation Medicine, Jiangsu Higher Education Institutions, Suzhou University, Suzhou 215123, China
4Division of Radiation Medicine, Department of Naval Medicine, Second Military Medical University, Shanghai 200433, China
刊名: Bioinorganic Chemistry and Applications, 2016, Vol.2016
来源数据库: Hindawi Journal
DOI: 10.1155/2016/1642064
原始语种摘要: A zinc finger motif is an element of proteins that can specifically recognize and bind to DNA. Because they contain multiple cysteine residues, zinc finger motifs possess redox properties. Ionizing radiation generates a variety of free radicals in organisms. Zinc finger motifs, therefore, may be a target of ionizing radiation. The effect of gamma radiation on the zinc finger motifs in transcription factor IIIA (TFIIIA), a zinc finger protein, was investigated. TFIIIA was exposed to different gamma doses from 60Co sources. The dose rates were 0.20 Gy/min and 800 Gy/h, respectively. The binding capacity of zinc finger motifs in TFIIIA was determined using an electrophoretic mobility shift assay. We found that 1000 Gy of gamma radiation impaired the function of the zinc finger...
全文获取路径: Hindawi 
影响因子:1.165 (2012)

  • finger 梳形物
  • Finger 指状夹
  • radiation 辐射
  • gamma 伽马
  • residues 残余物
  • cysteine 胖胱氨酸
  • ionizing 电离的
  • thiol 硫羟
  • recognize 承认
  • transcription 地名转写