Effect of GAS6 and AXL Gene Polymorphisms on Adiposity, Systemic Inflammation, and Insulin Resistance in Adolescents
作者: Fone-Ching HsiaoYuh-Feng LinPo-Shiuan HsiehNain-Feng ChuYii-Der Ida ChenYi-Shing ShiehChang-Hsun HsiehChien-Hsing LeeTing-I LeeYi-Jen HungYi-Hao Yu
作者单位: 1Graduate Institute of Clinical Medicine, College of Medicine, Taipei Medical University, Taipei City 110, Taiwan
2Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei City 114, Taiwan
3Department of Physiology and Biophysics, National Defense Medical Center, Taipei City 114, Taiwan
4School of Public Health Department, National Defense Medical Center, Taipei City 114, Taiwan
5Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center, Torrance, CA 90509, USA
6Department of Oral Diagnosis and Pathology, School of Dentistry, Tri-Service General Hospital, National Defense Medical Center, Taipei City 114, Taiwan
7Division of Endocrinology and Metabolism, Wan Fang Hospital, Taipei Medical University, Taipei City 116, Taiwan
刊名: International Journal of Endocrinology, 2014, Vol.2014
来源数据库: Hindawi Journal
DOI: 10.1155/2014/674069
原始语种摘要: The present study was designed to explore the effects of GAS6 and AXL gene polymorphisms on adiposity, systemic inflammation, and insulin resistance in adolescents. After multistage sampling from the data of the Taipei Children Heart Study-III, we collected 358 boys and 369 girls with an average age of 13.3 years. We genotyped the adolescents’ GAS6 rs8191973, GAS6 rs8191974, AXL rs4802113, and AXL rs2304232 polymorphisms. Significantly higher body mass index (BMI), waist circumference (WC), and hsCRP levels were found in boys with the GG genotype of GAS6 rs8191974 than A allele carriers; higher IL-6 and insulin levels and increased HOMA-IR were found in boys with the GG genotype of AXL rs2304232 than the A allele carriers. There was a significant difference in hsCRP levels of boys with...
全文获取路径: Hindawi  (合作)
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影响因子:2.518 (2012)

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关键词翻译
关键词翻译
  • adiposity 肥胖
  • GAS Gasoline
  • insulin 胰岛素
  • inflammation 炎症
  • systemic 系统的
  • found 创立
  • circumference 圆周
  • waist 紧身胸衣
  • higher 
  • increased 增加