“The Mind Is Its Own Place”: Amelioration of Claustrophobia in Semantic Dementia
作者: Camilla N. ClarkLaura E. DowneyHannah L. GoldenPhillip D. FletcherRajith de SilvaAlberto CifelliJason D. WarrenArgye E. Hillis
作者单位: 1Dementia Research Centre, UCL Institute of Neurology, University College London, 8-11 Queen Square, London WC1N 3BG, UK
2Essex Neurosciences Centre, Queen’s Hospital, Rom Valley Way, Romford RM7 0AG, UK
刊名: Behavioural Neurology, 2014, Vol.2014
来源数据库: Hindawi Journal
DOI: 10.1155/2014/584893
原始语种摘要: Phobias are among the few intensely fearful experiences we regularly have in our everyday lives, yet the brain basis of phobic responses remains incompletely understood. Here we describe the case of a 71-year-old patient with a typical clinicoanatomical syndrome of semantic dementia led by selective (predominantly right-sided) temporal lobe atrophy, who showed striking amelioration of previously disabling claustrophobia following onset of her cognitive syndrome. We interpret our patient’s newfound fearlessness as an interaction of damaged limbic and autonomic responsivity with loss of the cognitive meaning of previously threatening situations. This case has implications for our understanding of brain network disintegration in semantic dementia and the neurocognitive basis of phobias more...
全文获取路径: Hindawi 
影响因子:1.247 (2012)

  • claustrophobia 幽闭恐怖
  • interpret 说明
  • understood 明白
  • striking 引燃
  • everyday 日常
  • lives 生命
  • meaning 意义
  • semantic 语义上的
  • dementia 痴呆
  • fearful 可怕的