Behavioral Improvement and Regulation of Molecules Related to Neuroplasticity in Ischemic Rat Spinal Cord Treated with PEDF
作者: Chary Marquez BatistaLeonardo Luis Torres BianquiBruno Bonganha ZanonMauricio Menezes Aben Athar IvoGabriela Pintar de OliveiraJessica Ruivo MaximinoGerson ChadiLeszek Kaczmarek
作者单位: 1Neuroregeneration Center, Department of Neurology, School of Medicine, University of São Paulo, Avenida Dr. Arnaldo 455, 2nd Floor, Room 2119, 01246-903-São Paulo, SP, Brazil
刊名: Neural Plasticity, 2014, Vol.2014
来源数据库: Hindawi Journal
DOI: 10.1155/2014/451639
原始语种摘要: Pigment epithelium derived factor (PEDF) exerts trophic actions to motoneurons and modulates nonneuronal restorative events, but its effects on neuroplasticity responses after spinal cord (SC) injury are unknown. Rats received a low thoracic SC photothrombotic ischemia and local injection of PEDF and were evaluated behaviorally six weeks later. PEDF actions were detailed in SC ventral horn (motor) in the levels of the lumbar central pattern generator (CPG), far from the injury site. Molecules related to neuroplasticity (MAP-2), those that are able to modulate such event, for instance, neurotrophic factors (NT-3, GDNF, BDNF, and FGF-2), chondroitin sulfate proteoglycans (CSPG), and those associated with angiogenesis and antiapoptosis (laminin and Bcl-2) and Eph (receptor)/ephrin system...
全文获取路径: Hindawi 
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关键词翻译
关键词翻译
  • 硫酸盐 增加
  • neurotrophic 神经营养的
  • lumbar 腰的
  • chondroitin 软骨碱
  • actions 对策
  • epithelium 上皮
  • receptor 接受体
  • injury 损害
  • laminin 层粘连蛋白
  • increased 增加
  • sulfate 增加