Role of Microglia Adenosine A<sub>2A</sub> Receptors in Retinal and Brain Neurodegenerative Diseases
作者: Ana R. SantiagoFilipa I. BaptistaPaulo F. SantosGonçalo CristóvãoAntónio F. AmbrósioRodrigo A. CunhaCatarina A. GomesJesús Pintor
作者单位: 1Centre of Ophthalmology and Vision Sciences, IBILI, Faculty of Medicine, University of Coimbra, 3000-548 Coimbra, Portugal
2AIBILI, 3000-548 Coimbra, Portugal
3Center for Neuroscience and Cell Biology, Largo Marquês de Pombal, Universidade de Coimbra, 3004-517 Coimbra, Portugal
4Faculty of Medicine, University of Coimbra, Azinhaga de Santa Comba, Celas, 3000-548 Coimbra, Portugal
5Department of Life Sciences, Calçada Martim de Freitas, 3000-456 Coimbra, Portugal
刊名: Mediators of Inflammation, 2014, Vol.2014
来源数据库: Hindawi Journal
DOI: 10.1155/2014/465694
原始语种摘要: Neuroinflammation mediated by microglial cells in the brain has been commonly associated with neurodegenerative diseases. Whether this microglia-mediated neuroinflammation is cause or consequence of neurodegeneration is still a matter of controversy. However, it is unequivocal that chronic neuroinflammation plays a role in disease progression and halting that process represents a potential therapeutic strategy. The neuromodulator adenosine emerges as a promising targeting candidate based on its ability to regulate microglial proliferation, chemotaxis, and reactivity through the activation of its G protein coupled A 2A receptor ( A 2 A R ). This is in striking agreement with the ability of A 2 A R blockade to control several brain diseases. Retinal degenerative diseases have been also...
全文获取路径: Hindawi 
影响因子:3.882 (2012)

  • sub 分段
  • potential 
  • degenerative 退化的
  • therapeutic 治疗的
  • unequivocal 不容置疑
  • targeting 导向目标
  • halting 暂停
  • brain 
  • associated 相关的
  • chemotaxis 签性