P2Y<sub>12</sub> Receptor on the Verge of a Neuroinflammatory Breakdown
作者: Susanna AmadioChiara ParisiCinzia MontilliAlberto Savio CarrubbaSavina ApolloniCinzia VolontéJesús Pintor
作者单位: 1Santa Lucia Foundation, Via del Fosso di Fiorano 65, 00143 Rome, Italy
2Cellular Biology and Neurobiology Institute (CNR), Via del Fosso di Fiorano 65, 00143 Rome, Italy
刊名: Mediators of Inflammation, 2014, Vol.2014
来源数据库: Hindawi Journal
DOI: 10.1155/2014/975849
原始语种摘要: In the CNS, neuroinflammation occurring during pathologies as amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) is the consequence of an intricate interplay orchestrated by various cell phenotypes. Among the molecular cues having a role in this process, extracellular nucleotides are responsible for intercellular communication and propagation of inflammatory stimuli. This occurs by binding to several receptor subtypes, defined P2X/P2Y, which are widespread in different tissues and simultaneously localized on multiple cells. For instance, the metabotropic P2Y12 subtype is found in the CNS on microglia, affecting activation and chemotaxis, on oligodendrocytes, possessing a hypothesized role in myelination, and on astrocytes. By comparative analysis, we have...
全文获取路径: Hindawi 
影响因子:3.882 (2012)

  • microglia 小神经胶质细胞
  • ALS Accumulator Left Shift
  • sclerosis 硬化
  • sub 分段
  • ramified 分枝的
  • potentially 可能地
  • amyotrophic 肌肉萎缩的
  • cerebellum 小脑
  • myelination 髓鞘生成
  • striatum 纹状体