Prediabetes Is Associated with HNF-4 α P2 Promoter Polymorphism rs1884613: A Case-Control Study in Han Chinese Population and an Updated Meta-Analysis
作者: Changyi WangSihan ChenTao ZhangZhongwei ChenShengyuan LiuXiaolin PengJianping MaXiaohong ZhongYanqiong YanLinlin TangYifeng MaiLiyuan HanShiwei DuanStamatios Theocharis
作者单位: 1Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen 518054, China
2Shenzhen Shekou People's Hospital, Shenzhen 518067, China
3The Affiliated Hospital, School of Medicine, Ningbo University, Ningbo, Zhejiang 315000, China
4School of Medicine, Zhejiang Provincial Key Laboratory of Pathophysiology, Diabetes Center, Ningbo University, Ningbo 315211, China
刊名: Disease Markers, 2014, Vol.2014
来源数据库: Hindawi Journal
DOI: 10.1155/2014/231736
原始语种摘要: Background . Controversy remains for the association between hepatocyte nuclear factor 4α ( HNF-4α ) P2 promoter polymorphism rs1884613 and type 2 diabetes (T2D). There was no association test of this polymorphism with prediabetes and T2D in the Chinese population. Moreover, an updated meta-analysis in various ethnic groups is needed to establish the contribution of rs1884613 to T2D risk. Methods . Using the Sequenom MassARRAY platform approach, we genotyped rs1884613 of HNF-4α in the P2 promoter region among 490 T2D patients, 471 individuals with prediabetes, and 575 healthy controls. All the individuals were recruited from 16 community health service centers in Nanshan district in Shenzhen province. Using STATA 11.0 software, meta-analysis was performed to summarize the overall...
全文获取路径: Hindawi  (合作)
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影响因子:2.14 (2012)

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关键词翻译
关键词翻译
  • prediabetes 前驱糖尿病
  • susceptibility 磁化率
  • whole 全部的
  • controls 控制机构
  • hepatocyte 肝细胞
  • analysis 分析
  • remains 残渣
  • contribution 贡献
  • centers 机组间距
  • promoter 催化剂