The Effects of Baclofen for the Treatment of Gastroesophageal Reflux Disease: A Meta-Analysis of Randomized Controlled Trials
作者: Shujie LiShengying ShiFeng ChenJingming LinSpiros D. Ladas
作者单位: 1Department of Pharmacy, Zhujiang Hospital, Southern Medical University, No. 253 Industrial Road, Haizhu District, Guangzhou 510282, China
刊名: Gastroenterology Research and Practice, 2014, Vol.2014
来源数据库: Hindawi Journal
DOI: 10.1155/2014/307805
原始语种摘要: Objectives . Baclofen can relieve gastroesophageal reflux-related symptoms in healthy subjects and gastroesophageal reflux disease (GERD) patients by reducing the incidence of transient lower esophageal sphincter relaxation. This meta-analysis aimed to evaluate the efficacy and safety of baclofen for the treatment of GERD. Methods . We systematically searched randomized controlled trials published prior to November 2013 from PubMed, Medline, Embase, ScienceDirect, ClinicalTrials.gov, and the Cochrane Central Register of Randomized Controlled Trials. We performed a meta-analysis of all eligible trials. Results . Nine studies were identified with a total of 283 GERD patients and healthy subjects. Comparative analysis provided high quality data supporting the ability of baclofen to promote a...
全文获取路径: Hindawi 
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影响因子:1.615 (2012)

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关键词翻译
关键词翻译
  • baclofen 巴氯芬
  • sphincter 括约肌
  • events 定时
  • reflux 逆流回流
  • esophageal 食管的
  • incidence 入射
  • adverse 逆的
  • analysis 分析
  • serious 认真的
  • treatment 处理