CLCA2 as a Novel Immunohistochemical Marker for Differential Diagnosis of Squamous Cell Carcinoma from Adenocarcinoma of the Lung
作者: Kazuya ShinmuraHisaki IgarashiHisami KatoYuichi KawanishiYusuke InoueSatoki NakamuraHiroshi OgawaTakashi YamashitaAkikazu KawaseKazuhito FunaiHaruhiko SugimuraStamatios Theocharis
作者单位: 1Department of Tumor Pathology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, Shizuoka 431-3192, Japan
2Research Equipment Center, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan
3Department of Internal Medicine 2, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan
4Division of Pathology, Seirei Mikatahara General Hospital, Hamamatsu 433-8558, Japan
5Department of Surgery 1, Hamamatsu University School of Medicine, Hamamatsu 431-3192, Japan
刊名: Disease Markers, 2014, Vol.2014
来源数据库: Hindawi Journal
DOI: 10.1155/2014/619273
原始语种摘要: Recent progress in targeted therapy for lung cancer has revealed that accurate differential diagnosis between squamous cell carcinoma (SCC) and adenocarcinoma (ADC) of the lung is essential. To identify a novel immunohistochemical marker useful for differential diagnosis between the two subtypes of lung cancer, we first selected 24 SCC-specific genes and 6 ADC-specific genes using data (case number, 980) from the Cancer Genome Atlas (TCGA) database. Among the genes, we chose the CLCA2 gene, which is involved in chloride conductance and whose protein expression in lung cancer is yet to be characterized, and evaluated its protein expression status in 396 cases of primary lung cancer at Hamamatsu University Hospital. Immunohistochemical analysis revealed a significantly higher CLCA2...
全文获取路径: Hindawi 
影响因子:2.14 (2012)

  • expression 表示
  • ADC Analog-Digital Conversion
  • marker 标试器
  • protein 蛋白质
  • higher 
  • novel 长篇小说
  • differential 差动的
  • specific 
  • whose 谁的
  • targeted 对准目标的