Assessment of Glomerular Filtration Rate Based on Alterations of Serum Brain-Derived Neurotrophic Factor in Type 2 Diabetic Subjects Treated with Amlodipine/Benazepril or Valsartan/Hydrochlorothiazide
作者: I-Te LeeWayne Huey-Herng SheuYi-Jen HungJung-Fu ChenChih-Yuan WangWen-Jane LeeGiuseppe Murdaca
作者单位: 1Division of Endocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan
2School of Medicine, Chung Shan Medical University, Taichung 40201, Taiwan
3School of Medicine, National Yang-Ming University, Taipei 11221, Taiwan
4Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan
5Division of Endocrinology and Metabolism, Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung 83301, Taiwan
6Division of Endocrinology and Metabolism, Department of Internal Medicine, National Taiwan University Hospital, Taipei 10617, Taiwan
7Department of Medical Research, Taichung Veterans General Hospital, Taichung 40705, Taiwan
刊名: Disease Markers, 2015, Vol.2015
来源数据库: Hindawi Journal
DOI: 10.1155/2015/780743
原始语种摘要: Background . Brain-derived neurotrophic factor (BDNF) is associated with sympathetic activation. However, the effects of BDNF on diabetic nephropathy are unknown. The aim of this study was to assess the estimated glomerular filtration rates (eGFRs) and changes in serum BDNF levels in type 2 diabetic subjects treated with antihypertensive medications. Methods . In this randomized, double-blind clinical trial, type 2 diabetic subjects with hypertension were assigned to either the benazepril/amlodipine or valsartan/hydrochlorothiazide treatment groups for a 16-week period. The post hoc analyses were based on increased or decreased serum BDNF levels. Results . Of the 153 enrolled subjects, the changes in eGFR were significantly and inversely correlated with those in BDNF in the 76 subjects...
全文获取路径: Hindawi  (合作)
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影响因子:2.14 (2012)

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关键词翻译
关键词翻译
  • diabetic 糖尿病患者
  • hypertension 高血压
  • reduced 减缩的
  • nephropathy 肾病
  • treated 加工的
  • inversely 相反地
  • serum 血清
  • neurotrophic 神经营养的
  • glomerular 肾小球病
  • factor 因素