Protective Effect of Artemisia asiatica Extract and Its Active Compound Eupatilin against Cisplatin-Induced Renal Damage
作者: Jun Yeon ParkDahae LeeHyuk-Jai JangDae Sik JangHak Cheol KwonKi Hyun KimSu-Nam KimGwi Seo HwangKi Sung KangDae-Woon EomAvni Sali
作者单位: 1College of Korean Medicine, Gachon University, Seongnam 461-701, Republic of Korea
2Department of Surgery, University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung 210-711, Republic of Korea
3Department of Life and Nanopharmaceutical Science, College of Pharmacy, Kyung Hee University, Seoul 130-701, Republic of Korea
4Natural Products Research Center, Korea Institute of Science and Technology, Gangneung 210-340, Republic of Korea
5School of Pharmacy, Sungkyunkwan University, Suwon 440-746, Republic of Korea
6Department of Pathology, University of Ulsan College of Medicine, Gangneung Asan Hospital, Gangneung 210-711, Republic of Korea
刊名: Evidence-Based Complementary and Alternative Medicine, 2015, Vol.2015
来源数据库: Hindawi Journal
DOI: 10.1155/2015/483980
原始语种摘要: The present study investigated the renoprotective effect of an Artemisia asiatica extract and eupatilin in kidney epithelial (LLC-PK1) cells. Although cisplatin is effective against several cancers, its use is limited due to severe nephrotoxicity. Eupatilin is a flavonoid compound isolated from the Artemisia plant and possesses antioxidant as well as potent anticancer properties. In the LLC-PK1 cellular model, the decline in cell viability induced by oxidative stress, such as that induced by cisplatin, was significantly and dose-dependently inhibited by the A. asiatica extract and eupatilin. The increased protein expressions of phosphorylated JNK and p38 by cisplatin in cells were markedly reduced after A. asiatica extract or eupatilin cotreatment. The elevated expression of cleaved...
全文获取路径: Hindawi 
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关键词翻译
关键词翻译
  • cisplatin 顺氯氨铂
  • against 反对
  • nephrotoxicity 中毒性肾损害
  • cells 麻风细胞
  • significantly 较大地
  • induced 感应的
  • potent 强大的
  • reduced 减缩的
  • anticancer 抗癌的
  • epithelial 上皮的