In Vitro Safety Evaluation and In Vivo Imaging Studies of Superparamagnetic Iron Oxide Nanoparticles through Biomimetic Modification
作者: Xinfeng SongYancong ZhangHanwen SunPingxuan DongZhongyu ZhangJing LiuManikandan Muthu
作者单位: 1Shandong Provincial Engineering Laboratory of Novel Pharmaceutical Excipients, Sustained and Controlled Release Preparations, College of Medicine and Nursing, Dezhou University, Decheng District, Dezhou 253023, China
2Dezhou People’s Hospital, Decheng District, Dezhou 253014, China
3School of Stomatology, Shandong University, China
刊名: Journal of Nanomaterials, 2019, Vol.2019
来源数据库: Hindawi Journal
DOI: 10.1155/2019/9827625
原始语种摘要: Magnetic resonance imaging (MRI) is an advanced medical imaging diagnostic technique that utilizes different resonance signals generated by the signal strength of water content and the relaxation time of protons in water molecules under the influence of an external magnetic field. This technique requires contrast agents, such as Gd-DTPA and Gd-DOTA, which could increase the risk of renal fibrosis in patients with severe renal insufficiency. The magnetic moment or susceptibility of superparamagnetic iron oxide nanoparticle (SPION) is higher than that of other paramagnetic substances and could significantly reduce the dosage of the contrast agent required. In our previous work, the novel magnetic composite nanoparticles (abbreviated as c(RGDyK)-PDA-SPION) had been successfully synthesized...
全文获取路径: Hindawi  (合作)
影响因子:1.547 (2012)

  • imaging 图像形成
  • resonance 共振
  • paramagnetic 顺磁性的
  • MRI Machine-Readable Information
  • contrast 差异
  • weighted 加权
  • renal 肾的
  • insufficiency 机能不全
  • relaxation 松弛
  • enrichment 富集