HCV-Induced Oxidative Stress: Battlefield-Winning Strategy
作者: Khadija RebbaniKyoko Tsukiyama-KoharaMaria G. Isaguliants
作者单位: 1Department of Animal Hygiene, Joint Faculty of Veterinary Medicine, Kagoshima University, Kagoshima 890-0065, Japan
刊名: Oxidative Medicine and Cellular Longevity, 2016, Vol.2016
来源数据库: Hindawi Journal
DOI: 10.1155/2016/7425628
原始语种摘要: About 150 million people worldwide are chronically infected with hepatitis C virus (HCV). The persistence of the infection is controlled by several mechanisms including the induction of oxidative stress. HCV relies on this strategy to redirect lipid metabolism machinery and escape immune response. The 3 β -hydroxysterol Δ24-reductase (DHCR24) is one of the newly discovered host markers of oxidative stress. This protein, as HCV-induced oxidative stress responsive protein, may play a critical role in the pathogenesis of HCV chronic infection and associated liver diseases, when aberrantly expressed. The sustained expression of DHCR24 in response to HCV-induced oxidative stress results in suppression of nuclear p53 activity by blocking its acetylation and increasing its interaction with MDM2...
全文获取路径: Hindawi  (合作)
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影响因子:3.393 (2012)

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关键词翻译
关键词翻译
  • oxidative 氧化的
  • reductase 还原酶
  • worldwide 世界的
  • protein 蛋白质
  • liver 
  • induced 感应的
  • stress 应力
  • acetylation 乙酰化
  • hepatitis 肝炎
  • redirect 重定向