Clinical Significance and Biological Role of HuR in Head and Neck Carcinomas
作者: Georgia LevidouIoly Kotta-LoizouJason TasoulasThomas PapadopoulosStamatios TheocharisMichal Barak
作者单位: 1First Department of Pathology, Medical School, National and Kapodistrian University of Athens, Athens, Greece
2Department of Pathology, Klinikum Nuremberg, Paracelsus Medical University, Nuremberg, Germany
3Department of Life Sciences, Faculty of Natural Sciences, Imperial College London, London, UK
刊名: Disease Markers, 2018, Vol.2018
来源数据库: Hindawi Journal
DOI: 10.1155/2018/4020937
原始语种摘要: Background. Hu-antigen R (HuR) is a posttranscriptional regulator of several target mRNAs, implicated in carcinogenesis. This review aims to present the current evidence regarding the biological role and potential clinical significance of HuR in head and neck carcinomas. Methods . The existing literature concerning HuR expression and function in head and neck carcinomas is critically presented and summarised. Results. HuR is expressed in the majority of the examined samples, showing higher cytoplasmic levels in malignant or premalignant cases. Moreover, HuR modulates several genes implicated in biological processes important for malignant transformation, growth, and invasiveness. HuR seems to be an adverse prognosticator in patients with OSCCs, whereas a correlation with a more aggressive...
全文获取路径: Hindawi 
影响因子:2.14 (2012)

  • carcinogenesis 癌形成
  • premalignant 恶变前的
  • prognosticator 预言者
  • invasiveness 侵入力
  • present 出席的
  • several 各自
  • regulator 第器
  • expressed 榨出的
  • regarding 涉及
  • examined 验讫