Effect of Amino Acids on the Generation of Ginsenoside Rg3 Epimers by Heat Processing and the Anticancer Activities of Epimers in A2780 Human Ovarian Cancer Cells
作者: Jun Yeon ParkPilju ChoiDahae LeeTaejung KimEun Bee JungBuyng-Su HwangKi Sung KangJungyeob HamMan Hee Rhee
作者单位: 1College of Korean Medicine, Gachon University, Seongnam 461-701, Republic of Korea
2KIST Gangneung Institute of Natural Products, Korea Institute of Science and Technology, Gangneung 210-340, Republic of Korea
刊名: Evidence-Based Complementary and Alternative Medicine, 2016, Vol.2016
来源数据库: Hindawi Journal
DOI: 10.1155/2016/3146402
原始语种摘要: Ginsenosides are the active components of Panax ginseng . Many research studies indicate that these deglycosylated, less-polar ginsenosides have better bioactivity than the major ginsenosides. In the present study, we sought to verify the enhanced anticancer effect of P. ginseng extract after undergoing the Maillard reaction as well as elucidate the underlying mechanism of action. The effects of 9 amino acids were tested; among them, the content of 20(S)-Rg3 in the ginseng extract increased to more than 30, 20, and 20% when processed with valine, arginine, and alanine, respectively, compared with that after normal heat processing. The ginseng extract that was heat-processed with arginine exhibited the most potent inhibitory effect on A2780 ovarian cancer cell proliferation. Therefore, the...
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关键词翻译
关键词翻译
  • expression 表示
  • ginseng 人参
  • arginine 精氨酸
  • effect 效应
  • less 更少的
  • increased 增加
  • confirmed 已确认的
  • whereas 鉴于
  • generation 世代
  • ovarian 卵巢的