Association between a Single Nucleotide Polymorphism in the 3 <mml:mrow> ′ -UTR of ARHGEF18 and the Risk of Nonidiopathic Pulmonary Arterial Hypertension in Chinese Population
作者: Ding LiYan SunXiaochao KongChangxing LuanYoujia YuFeng ChenPeng ChenTimo Sorsa
作者单位: 1Department of Forensic Medicine, Nanjing Medical University, Nanjing, Jiangsu 211166, China
2Department of Oncology, Jiangsu Cancer Hospital, Nanjing Medical University, Nanjing, Jiangsu 211166, China
3Forensic Expertise Institute, Nanjing Medical University, Nanjing, Jiangsu 211166, China
刊名: Disease Markers, 2018, Vol.2018
来源数据库: Hindawi Journal
DOI: 10.1155/2018/2461845
原始语种摘要: ARHGEF18 has been identified as upregulated in the lung tissues of rat models of pulmonary artery hypertension introduced by hypoxia or monocrotaline (MCT). We used online SNP function prediction tools to screen the candidate SNPs that might be associated with the regulation of the ARHGEF18 expression. The result suggested that rs3745357 located in the 3 ′ -untranslated region of ARHGEF18 is probably a genetic modifier in the process . In the present study, we aimed to investigate the association between ARHGEF18 rs3745357 polymorphism and nonidiopathic pulmonary arterial hypertension susceptibility (niPAH). A total of 293 participants were included in the case-control study (117 patients and 176 healthy controls). The rs3745357 variant was discriminated by using cleaved...
全文获取路径: Hindawi 
影响因子:2.14 (2012)

  • genetic 遗传的
  • divided 分部联箱
  • between 在中间
  • control 控制
  • region 地域
  • investigate 
  • expression 表示
  • significant 有效的
  • hypertension 高血压
  • susceptibility 磁化率