Objective: To evaluate the efficacy of corneal endothelial cell after femtosecond laser-assisted cataract surgery and conventional phacoemulsification cataract surgery, and compare the changes after two cataract surgery. Methods: Clinical data in our hospital from January 2017 to January 2018, which treated 86 cases (100 eyes) of cataract patients, were divided into two groups according to different types of operation. A group includes 46 cases (50 eyes), underwent femtosecond laser assisted cataract surgery; in the B group, 40 cases (50 eyes), underwent the conventional phacoemulsification cataract surgery. Corneal endothelial cell density, mean cell area, proportion of hexagonal cells and cell loss rate were observed preoperatively and 1 week, 1 month, 3 months postoperatively for the... two groups. Results: After the operation, the endothelial cell density and the proportion of hexagonal cells of the two groups all decreased, and mean cell area increased. The difference of corneal endothelial cell density, mean cell area, proportion of hexagonal cells, between before and after operation, was statistically significant, in the same time after operation, cell loss rate in group B was bigger than those in group A, the proportion of hexagonal cells in group B was smaller than those in group A. Conclusions: Femtosecond laser-assisted cataract surgery has a lower damage to corneal endothelial cell, and was a safe operation method.