The Preparation of 2-Fluorine Propionic Acid by Ultrasound Method
超声波法制备2-氟丙酸
作者: 舒浪田崎峰邵开元刘明胡文祥
作者单位: 1武汉工程大学化工与制药学院,武汉
2北京神剑天军医学科学院,北京
3首都师范大学生命科学学院,北京
刊名: Journal of Organic Chemistry Research, 2014, Vol.02 (04), pp.43-46
中文刊名: 有机化学研究, 2014, Vol.02 (04), pp.43-46
来源数据库: Hans Pubs Journal
DOI: 10.12677/JOCR.2014.24007
关键词: 2-Fluoro Propionic Acid
中文关键词: 2-氟丙酸,超声波,氟化反应,重氮化
英文摘要: In many drugs, fluorochemicals have a strong physiological activity. α-fluorine propionic acid is a small chiral organic molecule; since it has an asymmetric carbon, it has an important significance in application of organic synthesis and some drugs’ structural modification. In this paper, the syn-thesis of 2-fluorine propionic acid was studied, using fluorinated diazotization method and halogen fluorination method. It is a classic method of diazotization for fluorination. However, the reaction transformation rate is low when the method is applied to the synthesis of 2-fluorine propionic acid, which is only 14% in literatures. And the reaction transformation rate may be greatly improved by using fluoride (such as potassium fluoride) under ultrasonic condition compared with fluorinated...
中文摘要: 在许多药物中,含氟类化合物,具有极强的生理活性。α-氟代丙酸是一种手性小分子有机脂肪酸,由于它有一个手性碳,所以在合成应用和某些药物结构修饰中有着重要的意义。本文主要采用了重氮化氟化法和卤化物氟取代法,对α-氟代丙酸的合成进行了研究。重氮化氟化法是一种经典的氟化反应法。然而,应用该方法合成2-氟丙酸转化率较低,文献报道仅有14%。而使用氟化物(如氟化钾)在超声波的条件下直接氟化,其转化率相比重氮化氟化方法大为提高。
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