Study on the Construction of Nanocarriers Based on Mesoporous Silica
磁性介孔二氧化硅纳米药物载体的制备及其研究
作者: 周洋陶丽君万尹佳周原
作者单位: 1武汉工程大学,湖北 武汉
刊名: Journal of Comparative Chemistry, 2018, Vol.02 (02), pp.39-46
中文刊名: 比较化学, 2018, Vol.02 (02), pp.39-46
来源数据库: Hans Pubs Journal
DOI: 10.12677/CC.2018.22007
英文摘要: Human beings are working hard to conquer the cure of cancer and strive to explore the methods and techniques of treating cancer. The preparation of magnetic mesoporous silica nano-drug carrier provides a new research direction for cancer treatment. Fe3O4 nanoparticles were prepared by solvothermal method. SiO2 was coated on the surface of Fe3O4 with CTAB as template. Then the template was stirred in the ethanol solution of NaCl to form mesopores outside Fe3O4. In the ex-periment, the magnetic mesoporous silica nanometer drug carrier with good morphology was prepared by controlling the time of the coating and changing the amount of TEOS. Finally, the op-timum dosage of TEOS was about 150 μl when the time was 6 hours. Finally, Fe3O4@mSiO2 was modified by surface thiolation, so that the...
中文摘要: 人们正在努力攻克癌症的治愈,努力探索治疗癌症的方法与技术。磁性介孔二氧化硅纳米药物载体的制备给癌症治疗提供了一个新的研究方向。利用共沉淀法制备Fe3O4纳米粒子,用CTAB做模板剂在Fe3O4的表面包裹SiO2,随后在NaCl的乙醇溶液中搅拌去模版基,使Fe3O4外面形成介孔。实验中通过控制包裹时间,改变TEOS的用量,制备成形貌良好的磁性介孔二氧化硅纳米药物载体。最后对Fe3O4@mSiO2进行表面巯基化修饰,使表面巯基化的Fe3O4@mSiO2不仅能通过介孔载药,还能通过化学键载药,提高载体载药率。磁性介孔二氧化硅纳米药物载体的成功制备,为癌症治疗的靶向治疗带来新的研究方向。
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