Residues in the N-Terminal Domain of MutL Required for Mismatch Repair in Bacillus subtilis
作者: Nicholas J. BolzJustin S. LenhartSteven C. WeindorfLyle A. Simmons
刊名: Journal of Bacteriology, 2012, Vol.194 (19), pp.5361-5367
来源数据库: Highwire期刊
DOI: 10.1128/JB.01142-12
原始语种摘要: Mismatch repair is a highly conserved pathway responsible for correcting DNA polymerase errors incorporated during genome replication. MutL is a mismatch repair protein known to coordinate several steps in repair that ultimately results in strand removal following mismatch identification by MutS. MutL homologs from bacteria to humans contain well-conserved N-terminal and C-terminal domains. To understand the contribution of the MutL N-terminal domain to mismatch repair, we analyzed 14 different missense mutations in Bacillus subtilis MutL that were conserved with missense mutations identified in the human MutL homolog MLH1 from patients with hereditary nonpolyposis colorectal cancer (HNPCC). We characterized missense mutations in or near motifs important for ATP binding, ATPase activity,...
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影响因子:3.194 (2012)

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关键词翻译
关键词翻译
  • several 各自
  • mismatch 不匹配
  • mutant 突变体
  • protein 蛋白质
  • missense 错义
  • binding 装订
  • functional 功能的
  • Domain 区域
  • remaining 剩余
  • maintain