With pharmaceutical companies’ repeated failures at finding effective interventions forAlzheimer’s disease, together with an increasing reliance on the growing Federal funding for research, thereis an emergent opportunity for financing alternate research through crowdfunding. Crowdfundingwhere fundingis obtained from small donations from a large group of peoplehas become a new source of funding for medicalresearch. By understanding how the research community has evolved to study Alzheimer’s disease the pitfallsof this strategy can be highlighted. Alzheimer’s disease research is complex. From its inception in the early1900s, Alzheimer’s disease has been at the center of movement within psychiatry to define the disease on thebasis of its biology. Recent emphasisthrough the DSM (Diagnostic... and Statistical Manual of Mental Disorders),RDoC (Research Diagnostic Criteria), RDoC (Research Domain Criteria) as well as the more recent Frameworkfrom the U.S. National Institute on Aginghave supported an exclusive emphasis on biology. But by excludingother aspects of the disease, such as its clinical expression, this research approach will be shown to be faultyand contradictory. So far this approach has resulted in 100% failures. By examining the historical and financialcircumstances of the industry centered on Alzheimer’s disease a strong warning is given to the public to mistrustcrowdfunding Alzheimer’s disease research. A broader and more inclusive approach is likely to generate a betterunderstanding of the disease and therefore hold better promise for understanding the disease in the long term.Such a nuance approach competes badly with the more binary search for a cure and is less receptive to publicsupport through crowdfunding.