Quinine induced thrombotic microangiopathy and thrombocytopenia: A teaching hospital's perspective
作者: Aaron J. FrankeWilliam Paul Skelton IV
刊名: Advances in General Practice of Medicine, 2019, Vol.1 (1)
来源数据库: SyncSci Publishing
DOI: 10.25082/AGPM.2019.01.003
关键词: QuinineTMADrug reactionDITMAThrombocytopenia
原始语种摘要: Although quinine is an infrequently prescribed drug, with malaria treatment being its onlyFDA-approved indication, unwitting exposure via beverages (e.g., tonic water), over the counter herbal remediesand illegal recreation drugs still occur. We present a unique case of a female patient who denied any known priorhistory of quinine exposure, who after being prescribed quinine tablets for restless leg syndrome, developed animmune-related thrombotic microangiopathy with thrombocytopenia and subsequent multi-organ failure. It waslater elucidated that her only known potential source of prior quinine exposure was a remote history of crack-cocaine use. The patient survived this rare and severe inflammatory response with recovery of renal functionand was able to discontinue dialysis
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  • quinine 奎宁
  • induced 感应的
  • thrombotic 血栓形成的
  • hospital 医院
  • tablets 平片体
  • exposure 暴露
  • cocaine 可卡因
  • dialysis 透析
  • teaching 教学
  • malaria 疟疾