Patent ductus arteriosus: patho-physiology, hemodynamic effects and clinical complications
作者: Giovanbattista CapozziGiuseppe Santoro
作者单位: 1Paediatric Cardiology Unit, Second University of Naples, Monaldi Hospital , Naples , Italy
刊名: Journal of Maternal-Fetal and Neonatal Medicine, 2011, Vol.24 (S1), pp.15-16
来源数据库: Informa Journal
DOI: 10.3109/14767058.2011.607564
原始语种摘要: During fetal life, patent arterial duct diverts placental oxygenated blood from the pulmonary artery into the aorta by-passing lungs. After birth, decrease of prostacyclins and prostaglandins concentration usually causes arterial duct closure. This process may be delayed, or may even completely fail in preterm infants with arterial duct still remaining patent. If that happens, blood flow by-pass of the systemic circulation through the arterial duct results in pulmonary overflow and systemic hypoperfusion. When pulmonary flow is 50% higher than systemic flow, a hemodynamic “paradox” results, with an increase of left ventricular output without a subsequent increase of systemic output. Cardiac overload support neuro-humoral effects (activation of sympathetic nervous system and...
全文获取路径: Informa Healthcare 

  • arterial 动脉的
  • ductus 
  • hemodynamic 血液动力的
  • pulmonary 肺的
  • systemic 系统的
  • patho 
  • perfusion 灌注
  • effect 效应
  • insufficiency 机能不全
  • patent 专利的