The effect of hyperglycemia on neonatal immune responses in-vitro
作者: Petra TemmingBirte Tr&oumlgerSusanne ThonnissenPaul-martin HolterhusChristian SchultzChristoph H&aumlrtel
作者单位: 11 Department of Paediatrics, University Hospital Schleswig-Holstein , Campus Lübeck , Germany
22 Department of Paediatrics, St. Bonifatius Hospital Lingen , Germany
33 Department of Paediatrics, Division of Paediatric Endocrinology and Diabetes, University Hospital Schleswig-Holstein , Campus, Kiel , Germany
44 University Hospital Hamburg, Department of Paediatric Oncology , Germany
刊名: Journal of Maternal-Fetal and Neonatal Medicine, 2012, Vol.25 (1), pp.94-98
来源数据库: Informa Journal
DOI: 10.3109/14767058.2011.557106
原始语种摘要: Introduction.  Acute hyperglycemia is considered as a pro-inflammatory state and is related to an adverse outcome in critically ill adults. Neonates are susceptible to infections and systemic inflammatory response syndrome induced by pro-inflammatory cytokines. This study focuses on the interaction between neonatal glucose homeostasis and the pro-inflammatory cytokine production in term and preterm infants in-vitro. Methods.  We analyzed the pro-inflammatory cytokine production in whole cord blood of term infants ( n  = 10), preterm infants > 32 weeks ( n =16) and preterm infants ≤32 weeks of gestational age ( n  = 13) and in adult controls ( n =14) using an in-vitro sepsis-model. Whole blood was pre-incubated...
全文获取路径: Informa Healthcare 

  • hyperglycemia 高血糖
  • neonatal 新生儿的
  • vitro 体外
  • cytokine 细胞因子
  • glucose 葡萄糖
  • insulin 胰岛素
  • homeostasis 体内平衡
  • immune 免疫的
  • inflammatory 激怒的
  • stimulated 受激