Polymorphisms in TSHR and IL1RN genes and the risk and prognosis of Hashimoto’s thyroiditis
作者: Ines ZaaberSouhir MestiriHela MarmouchSilvia MahjoubNabil AbidMohsen HassineBesma Bel Hadj Jrad-TensaoutKhaled Said
作者单位: 11 Laboratory of Genetics, Biodiversity and Bioresource Valorization, Superior Institute of Biotechnology of Monastir, University of Monastir , Monastir , Tunisia ,
22 Department of Internal Medicine-Endocrinology, Hospital Fattouma Bourguiba , Monastir , Tunisia ,
33 Laboratory of Transmissible Diseases and Biological Active Substances , and
44 Hematology Laboratory, Faculty of Pharmacy of Monastir, University of Monastir , Monastir , Tunisia
刊名: Autoimmunity, 2013, Vol.47 (2), pp.113-118
来源数据库: Informa Journal
DOI: 10.3109/08916934.2013.866101
原始语种摘要: Abstract Hashimoto’s thyroiditis (HT) is a complex genetic autoimmune thyroid disease (AITD). Thyroid-stimulating hormone receptor (TSHR) is considered as candidate gene in AITD. IL1RN gene is involved in the pathogenesis of a number of autoimmune diseases. These findings prompted us to investigate the association of TSHR and IL1RN genes polymorphism with the risk and the prognosis of HT in Tunisia. A total of 249 healthy controls and 202 patients with HT were genotyped for TSHR D727E and IL1RNVNTR polymorphism. No significant difference was found for D727E polymorphism between HT patients and healthy controls. For IL1RN gene, we found an association between HT and IL1RNVNTR polymorphism. The A1A3 genotype was more prevalent in HT patients than in controls....
全文获取路径: Informa Healthcare 
影响因子:2.767 (2012)

  • thyroiditis 甲状腺炎
  • prognosis 预报
  • VNTR 变数串联重复
  • polymorphism 多晶形
  • found 创立
  • controls 控制机构
  • associated 相关的
  • stimulating 促进
  • susceptibility 磁化率
  • severity 严重性