Irreversible optic neuritis after infliximab treatment in a patient with ulcerative colitis
作者: Kaare ClemmensenNeven AkrawiMarek Stawowy
作者单位: 11 Department of Ophthalmology, Aarhus University Hospital , Aarhus , Denmark
22 Department of Internal Medicine and Hepatolo-Gastroenterology Unit, Randers Hospital , Randers , Denmark
刊名: Scandinavian Journal of Gastroenterology, 2015, Vol.50 (12), pp.1508-1511
来源数据库: Informa Journal
原始语种摘要: Abstract This article reports the first known case of permanent blindness due to irreversible unilateral optic neuritis (ON) related to infliximab (Remicade) treatment of a patient with ulcerative colitis. A young male, with a family history of inflammatory bowel disease, was diagnosed with ulcerative colitis at the age of 20. He was treated with steroids and a 5-aminosalicylic acid drug without considerable effect, and later admitted to our hospital due to a relapse during reduction of the prednisolone dosage. A new colonoscopy showed moderate ulcerative colitis activity and the patient was declared as a steroid nonresponder. A treatment of 400 mg intravenous infliximab was initiated along with 150 mg/day of azathioprine (Imurel). Three days after the second infliximab treatment the...
全文获取路径: Informa Healthcare 
影响因子:2.156 (2012)

  • ulcerative 使...形成溃疡的
  • colitis 大肠炎
  • patient 有耐性的
  • treatment 处理
  • colonoscopy 结肠镜检查
  • steroid 甾族化合物
  • azathioprine 脒唑硫嘌呤
  • prednisolone 泼尼龙
  • nonresponder 无反应者
  • neuritis 神经炎