The impact of immunosuppressive therapy on QuantiFERON and tuberculin skin test for screening of latent tuberculosis in patients with inflammatory bowel disease scheduled for anti-TNF therapy
作者: Gerassimos J. MantzarisDimitrios TsironikosXanthipi TzanetakouEirini GrispouPantelis KaratzasIoannis KalogeropoulosKonstantinos Papamichael
作者单位: 11 Department of Gastroenterology, Evaggelismos Hospital , Athens , Greece
22 Department of Microbiology, Evaggelismos Hospital , Athens , Greece
33 Department of Radiology, Evaggelismos Hospital , Athens , Greece
刊名: Scandinavian Journal of Gastroenterology, 2015, Vol.50 (12), pp.1451-1455
来源数据库: Informa Journal
原始语种摘要: Abstract Objective. Patients with inflammatory bowel disease (IBD) should be routinely screened for latent tuberculosis (LTB) before starting anti-TNF therapy in order to prevent reactivation of LTB. Besides tuberculin skin test (TST), QuantiFERON-TB Gold In-Tube (QFT-G-IT) has gained wide acceptance as a screening strategy for LTB in IBD, although it may be negatively influenced by the prior use of immunomodulators (IMM) such as azathioprine or methotrexate. This study aimed to assess the impact of IMM on the TST and the QFT-G-IT for LTB screening in IBD patients scheduled for anti-TNF therapy. Material and methods. This observational, prospective, single-center study included consecutive IBD patients scheduled for anti-TNF therapy undergoing on the same day both TST and QFT-G-IT for...
全文获取路径: Informa Healthcare 
影响因子:2.156 (2012)

  • latent 潜在的
  • tuberculin 结核菌素
  • TST 试验
  • tuberculosis 肺结核
  • screening 筛分
  • control 控制
  • between 在中间
  • impact 冲击碰撞
  • group 
  • finally 最后