Concentration monitoring with near infrared chemical imaging in a tabletingpress
作者: Himmat DalviClémence Fauteux-LefebvreJean-Maxime GuayNicolas AbatzoglouRyan Gosselin
作者单位: 1Department of Chemical & Biotechnological Engineering, Pfizer Industrial ResearchChair, Université de Sherbrooke, 2500 boulevard de l’Université, Sherbrooke,Québec, Canada J1K 2R1.
2Department of Chemical and Biological Engineering, University of Ottawa, 161 LouisPasteur St, Ottawa, Ontario, Canada K1N 6N5.
3Process Analytical Sciences Group, Pfizer Global Supply, 1025 boulevard Marcel-Laurin,Saint-Laurent, Québec, Canada H4R 1J6
4Department of Chemical & Biotechnological Engineering, Pfizer Industrial ResearchChair, Université de Sherbrooke, 2500 boulevard de l’Université, Sherbrooke,Québec, Canada J1K 2R1.. Ryan.Gosselin@Usherbrooke.ca
刊名: Journal of Spectral Imaging, 2018, Vol.7 , pp.1-18
来源数据库: IM Publications
DOI: 10.1255/jsi.2018.a5
关键词: NIR spectroscopyNIR CIPATFeed frameIn-line monitoring
英文摘要: Monitoring powder potency and homogeneity is important in achieving real-time releasetesting in a continuous tablet manufacturing operation. If quality related issues are encountered, monitoringpowder potency inside a feed frame offers a last opportunity to intervene in the process before tabletcompression. Feed frame monitoring methods based on near infrared (NIR) spectroscopy have been increasinglyreported in recent years. New process analytical tools with the potential of being deployed alone or incombination with NIR spectroscopy for feed frame monitoring are now available commercially. The presentstudy evaluated the potential of near infrared chemical imaging (NIR CI) for in-line monitoring of a prototypepharmaceutical composition containing ascorbic acid (AA), microcrystalline...
原始语种摘要: Monitoring powder potency and homogeneity is important in achieving real-time releasetesting in a continuous tablet manufacturing operation. If quality related issues are encountered, monitoringpowder potency inside a feed frame offers a last opportunity to intervene in the process before tabletcompression. Feed frame monitoring methods based on near infrared (NIR) spectroscopy have been increasinglyreported in recent years. New process analytical tools with the potential of being deployed alone or incombination with NIR spectroscopy for feed frame monitoring are now available commercially. The presentstudy evaluated the potential of near infrared chemical imaging (NIR CI) for in-line monitoring of a prototypepharmaceutical composition containing ascorbic acid (AA), microcrystalline...
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关键词翻译
关键词翻译
  • chemical 化学的
  • monitoring 监视
  • concentrations 浓聚物
  • potential 
  • spectroscopy 分光学
  • imaging 图像形成
  • continuous 连续的
  • operation 运算
  • range 射程
  • inside 内部