PET Imaging of Integrin Positive Tumors Using 18F Labeled Knottin Peptides
作者: Shuanglong LiuHongguang LiuGang RenRichard H. KimuraJennifer R. CochranZhen Cheng
刊名: Theranostics, 2011, Vol.1 , pp.403-412
来源数据库: Ivyspring Journal
原始语种摘要: Purpose : Cystine knot (knottin) peptides, engineered to bind with high affinity to integrin receptors, have shown promise as molecular imaging agents in living subjects. The aim of the current study was to evaluate tumor uptake and in vivo biodistribution of 18F-labeled knottins in a U87MG glioblastoma model.;;Procedures : Engineered knottin mutants 2.5D and 2.5F were synthesized using solid phase peptide synthesis and were folded in vitro , followed by radiolabeling with 4-nitrophenyl 2-18F-fluoropropionate (18F-NFP). The resulting probes, 18F-FP-2.5D and 18F-FP-2.5F, were evaluated in nude mice bearing U87MG tumor xenografts using microPET and biodistribution studies.;;Results : MicroPET imaging studies with 18F-FP-2.5D...
全文获取路径: Ivyspring 

  • demonstrated 探明的储量
  • probes 探针
  • evaluate 求...的值
  • confirmed 已确认的
  • imaging 图像形成
  • promise 允诺
  • gallbladder 胆囊
  • uptake 上风口
  • glioblastoma 成胶质细胞瘤
  • mouse 小鼠