Trackable and Targeted Phage as Positron Emission Tomography (PET) Agent for Cancer Imaging
作者: Zibo LiQiaoling JinChiunwei HuangSiva DasaLiaohai ChenLi-peng YapShuanglong LiuHancheng CaiRyan ParkPeter S Conti
刊名: Theranostics, 2011, Vol.1 , pp.371-380
来源数据库: Ivyspring Journal
原始语种摘要: The recent advancement of nanotechnology has provided unprecedented opportunities for the development of nanoparticle enabled technologies for detecting and treating cancer. Here, we reported the construction of a PET trackable organic nanoplatform based on phage particle for targeted tumor imaging. Method: The integrin αvβ3 targeted phage nanoparticle was constructed by expressing RGD peptides on its surface. The target binding affinity of this engineered phage particle was evaluated in vitro. A bifunctional chelator (BFC) 1,4,7,10-tetraazadodecane-N,N',N",N"'-tetraacetic acid (DOTA) or 4-((8-amino-3,6,10,13,16,19-hexaazabicyclo [6.6.6] icosane-1-ylamino) methyl) benzoic acid (AmBaSar) was then conjugated to the phage surface for 64Cu2+...
全文获取路径: Ivyspring  (合作)
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关键词翻译
关键词翻译
  • phage 噬菌体
  • PET PagE frame Table
  • blocking 阻塞
  • demonstrated 探明的储量
  • receptor 接受体
  • specificity 特异性
  • imaging 图像形成
  • affinity 亲和力
  • targeted 对准目标的
  • significantly 较大地