Transforming a Targeted Porphyrin Theranostic Agent into a PET Imaging Probe for Cancer
作者: Jiyun ShiTracy W.B. LiuJuan ChenDavid GreenDavid JaffrayBrian C. WilsonFan WangGang Zheng
刊名: Theranostics, 2011, Vol.1 , pp.363-370
来源数据库: Ivyspring Journal
原始语种摘要: Porphyrin based photosensitizers are useful agents for photodynamic therapy (PDT) and fluorescence imaging of cancer. Porphyrins are also excellent metal chelators forming highly stable metallo-complexes making them efficient delivery vehicles for radioisotopes. Here we investigated the possibility of incorporating 64Cu into a porphyrin-peptide-folate (PPF) probe developed previously as folate receptor (FR) targeted fluorescent/PDT agent, and evaluated the potential of turning the resulting 64Cu-PPF into a positron emission tomography (PET) probe for cancer imaging. Noninvasive PET imaging followed by radioassay evaluated the tumor accumulation, pharmacokinetics and biodistribution of 64Cu - PPF. 64Cu - PPF uptake in FR-positive tumors was...
全文获取路径: Ivyspring 

  • PET PagE frame Table
  • radioassay 放射性分析
  • imaging 图像形成
  • uptake 上风口
  • targeted 对准目标的
  • blocking 阻塞
  • probe 探针
  • Cancer 巨蟹座
  • efficient 有用的