Evaluation of 111In-Labeled Cyclic RGD Peptides: Effects of Peptide and Linker Multiplicity on Their Tumor Uptake, Excretion Kinetics and Metabolic Stability
作者: Jiyun ShiYang ZhouSudipta ChakrabortyYoung-Seung KimBing JiaFan WangShuang Liu
刊名: Theranostics, 2011, Vol.1 , pp.322-340
来源数据库: Ivyspring Journal
原始语种摘要: Purpose: The purpose of this study was to demonstrate the valence of cyclic RGD peptides, P-RGD (PEG4-c(RGDfK): PEG4 = 15-amino-4,710,13-tetraoxapentadecanoic acid), P-RGD2 (PEG4-E[c(RGDfK)]2, 2P-RGD4 (E{PEG4-E[c(RGDfK)]2}2, 2P4G-RGD4 (E{PEG4-E[G3-c(RGDfK)]2}2: G3 = Gly-Gly-Gly) and 6P-RGD4 (E{PEG4-E[PEG4-c(RGDfK)]2}2) in binding to integrin αvβ3, and to assess the impact of peptide and linker multiplicity on biodistribution properties, excretion kinetics and metabolic stability of their corresponding 111In radiotracers.;;Methods: Five new...
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关键词翻译
关键词翻译
  • integrin 整联蛋白
  • affinity 亲和力
  • conjugates 接合藻类
  • glioma 神经胶质瘤
  • targeting 导向目标
  • binding 装订